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Darkstone

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Posts posted by Darkstone

  1. 20 minutes ago, Doggy said:

    So you never went Chasers " Outlaw - Loud & Fast " . It was like the Cathouse in St Kilda, but on Chapel St

    No unfortunately.

    "The Cathouse"  however was the ultimate. Didn't go as often as I would have liked, but loved everytime I went.

    There was more chance of "picking up" at the mainstream clubs, so that sealed the deal for us. 

     

  2. 2 hours ago, Metal T said:

    I also fully acknowledge the mental fallout that can occur on this...the late actor Michael Massee who shot Brandon Lee back in the early 90's said he quit acting for a coupla years to get his bearings back.I remember him saying in an interview that he got hate mail / death threats for years after that accident by people/fans who blamed him personally for it.

     

    It would be very hard to live with.

    The circumstances in this story from Rick Springfield are completely different, but I was reminded of it.

    I've seen him in other interviews, break down in tears when telling it.

     

     

     

    • Like 1
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  3. 7 hours ago, AlphaMale said:

    Now what?

    https://scitechdaily.com/covid-delta-and-delta-plus-variants-evade-the-antibody-response/

    COVID Delta and Delta Plus Variants Evade the Antibody Response

    By GERMAN PRIMATE CENTER OCTOBER 21, 2021

    COVID Variant Concept

    Cell culture studies show increased lung cell entry of the SARS-CoV-2 variants Delta and Delta Plus and reduced inhibition by antibodies.

    The emergence of new SARS-CoV-2 variants that can spread rapidly and undermine vaccine-induced immunity threatens the end of the COVID-19 pandemic.

     

    The delta variant (B.1.617.2) emerged in India and subsequently spread globally within a short time period. Also in Germany, almost all recent infections are due to this variant. In addition to Delta, so-called Delta Plus sub-variants have been observed, which carry additional mutations that may make them more dangerous.

    A research team led by Stefan Pöhlmann and Markus Hoffmann from the German Primate Center – Leibniz Institute for Primate Research in Göttingen and colleagues from the Hannover Medical School, the University of Göttingen Medical Center and the Friedrich-Alexander University of Erlangen-Nürnberg have investigated why the Delta variant spreads so efficiently and whether Delta Plus viruses are more dangerous.

    They were able to show that Delta and Delta Plus infect lung cells with higher efficiency than the original virus. In addition, one of four antibodies used to treat COVID-19 was not effective against Delta, and Delta Plus was even resistant against two therapeutic antibodies. Similarly, antibodies generated upon vaccination with the BioNTech-Pfizer and Oxford-AstraZeneca vaccines were also less effective against Delta and Delta Plus compared to the original virus. Delta and Delta Plus, on the other hand, were comparably inhibited, suggesting that Delta Plus may not pose a greater risk to vaccinated persons than Delta.

    Finally, it was found that individuals vaccinated first with Oxford-AstraZeneca and then with BioNTech-Pfizer had significantly more antibodies that inhibited Delta than individuals vaccinated twice with Oxford-AstraZeneca. The combination of two vaccines may thus induce a particularly strong immune protection against SARS-CoV-2 variants (The Lancet, Cell Reports, Cell Mol Immunol).

    Properties of SARS-CoV-2 Delta and Delta Plus Variants

    A) Summary of special properties of SARS-CoV-2 Delta and Delta Plus variants compared to the virus circulating to the beginning of the pandemic (wildtype virus). B) Heterologous vaccination with Oxford-AstraZeneca’s vector-based vaccine and BioNTech-Pfizer’s mRNA-based vaccine Induces the production of more neutralizing antibodies against the Delta variant than homologous (two-shot) vaccination with Oxford-AstraZeneca. Credit: Markus Hoffmann

    At present, more than 99 percent of SARS coronavirus 2 infections caused in Germany are due to the Delta variant, according to the Robert Koch Institute. Using cell culture experiments, a team of researchers led by Stefan Pöhlmann and Markus Hoffmann was able to show that Delta is better at entering lung cells compared to the original virus (the virus that circulated during the early phase of the pandemic). In addition, Delta is better at fusing infected lung cells with uninfected cells.

    “It is conceivable that by fusing cells in the respiratory tract, the Delta variant may spread more efficiently and induce more damage. This could contribute to a more severe course of COVID-19,” assumes Arora Prerna, scientist at the German Primate Center and first author of two studies specifically focusing on the Delta and Delta Plus variants.

    Monoclonal antibodies are used to treat COVID-19. These antibodies are proteins that are produced by genetic engineering. Unlike our immune system, which produces a large number of different antibodies against pathogens during infection, only individual antibodies or combinations of them are used for COVID-19 therapy. The team led by Stefan Pöhlmann and Markus Hoffmann studied four of these antibodies. They found that Delta is resistant against the antibody bamlanivimab, while Delta Plus is resistant against two antibodies, bamlanivimab and etesevimab, which are used in combination for treatment of COVID-19 patients.

    Delta and Delta Plus were less well inhibited (neutralized) by antibodies from infected and vaccinated individuals as compared to the original virus and this likely contributed to the rapid spread of Delta. A direct comparison of Delta and Delta Plus showed that both viruses were comparably neutralized. “This means that vaccination likely confers comparable protection against Delta and Delta Plus, and that Delta Plus is not significantly more dangerous than Delta,” says Stefan Pöhlmann.

    BioNTech-Pfizer’s vaccine is the most widely used vaccine in Europe, followed by Oxford-AstraZeneca’s vaccine. Due to very rare side effects following vaccination with Oxford-AstraZeneca, it is recommended in Germany and other countries that BioNTech-Pfizer is used for the second vaccination shot in people who have already received a first shot with Oxford-AstraZeneca. This strategy is referred to as heterologous vaccination.

    “Our studies show that heterologous vaccination induces significantly more neutralizing antibodies to Delta than two vaccination shots with Oxford-AstraZeneca. Individuals who have received such a heterologous vaccination may have a very good immune protection against Delta and Delta Plus,” says Markus Hoffmann.

    “Our results are consistent with the observation that vaccination efficiently protects against development of severe disease after infection with the Delta variant, but frequently fails to completely suppress infection. In light of the efficient protection against severe disease, the goal continues to be a high vaccination rate. This can prevent the health care system from being overwhelmed in case of increased spread of Delta and closely related viruses during the winter months,” says Stefan Pöhlmann.

    Reference: “B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination” by Prerna Arora, Anzhalika Sidarovich, Nadine Krüger, Amy Kempf, Inga Nehlmeier, Luise Graichen, Anna-Sophie Moldenhauer, Martin S. Winkler, Sebastian Schulz, Hans-Martin Jäck, Metodi V. Stankov, Georg M.N. Behrens, Stefan Pöhlmann and Markus Hoffmann, 27 September 2021, Cell Reports.
    DOI: 10.1016/j.celrep.2021.109825

    Well, there's only two options going forward. 

    Either, double down on the restrictions and inoculations or let it run and let the chips fall as they may.

     

     

  4. 16 minutes ago, Geoff said:

    Good on ya, mate. Now you can do, uh, nothing. Just like before you were vaccinated. :(

    But of course your "freedom day" is tomorrow, isn't it? Where you're finally free to do, uh, nothing. Just like before your freedom day. :(

     

     

     

     

    Yep.

    Now the talk is all about boosters. 

    Will they be mandatory? 

    Are we looking at annual mandatory injections?

     

  5. 41 minutes ago, Leykis101 said:

    Heres a couple of skanks who think it's funny to taunt me with their fucking pathetic semi pro football team that nobody's heard of, who are clearly no match for the Bucs, but since it's the one thing they know they can get under my skin with, they decided to be bitches and rub it in, knowing this, I did notice some absolutely great titties, and what better place to put this picture, then send them the link, LOL, people this is my cousin Jordyn and her friend Karlie, the 2 biggest sluts in Louisiana!

    49342015_161500151492832_997087524033658880_n.jpg

    Very nice mate.

  6. 29 minutes ago, Glen said:

    Agree but even more so.

    I think that pales against the original imo, which was a bona fide classic 

    100%.

    I posted the original recently. An alltime 80s favourite. 

    I also loved "Heart of Gold". Not HH fare at all, but many memories from the "old days" with these two tracks. 

     

     

     

  7. 1 hour ago, auslander said:

    True. You have to pick a team though. I'm on team Tate. I would love a reunion. Was just listening to Empire again on tge weekend. Love that album. Many love early Ryche the best but I love Mindcrime to Promise Land era the best.

    Initially I liked the newer albums but after a while they just don't have the replayability of ANY of the Tate-era albums, even the 2000s albums.

    Yeah, many before and since, but that run of "Mindcrime", "Empire" and "Promised Land" was awesome.

  8. 40 minutes ago, AlphaMale said:

    From Blabbermouth:

    OPERATION LAWSUIT & RUMORS … Scott Rockenfield ex-Queensryche drummer sues Eddie Jackson and Michael Wilton, reunion with Tate considered, La Torre on Thin Ice?

    Metal Sludge — In a brand new lawsuit, filed on Monday in a Snohomish County Court in the state of Washington, former Queensryche drummer Scott Rockenfield is suing his former band-mates and several related band companies.

    The suit filed on October 11th 2021, in a Snohomish County Court has Rockenfield suing Michael Wilton, Eddie Jackson, both of their wives who are also named, in addition Queensryche Holdings, LLC and Tri-Ryche Cooperation, Inc. among other related companies.

    An inside source close to the world that is Queensryche with direct knowledge of the latest happenings in addition to the lawsuit, has reached out to Metal Sludge directly.

    Our source Eric, is a long time associate (pka Dude Random on social media) and says he is close with multiple persons in the various and related Queensryche camps has told Metal Sludge a mouthful.

    http://metalsludge.tv/wp-content/uploads/2021/10/Queensyrche_La_Torre_Oct_15_2021_1-1.jpgTodd La Torre is the current voice of Queensryche, but our source says he is on ‘thin ice’ as there was a possible reunion that had been considered by original members, to rejoin with Geoff Tate.

    In short… Eric is claiming the following:

    * That it appears there was a possible reunion (yes, even with Chris DeGarmo) in the works, but it’s now f#@ked up due to Scott Rockenfield filing the lawsuit against Michael Wilton and Eddie Jackson.

    * What Scott Rockenfield is attempting is pretty f#@ked up states Eric noting parts of the lawsuit below:
    Breach of contract
    Shareholder oppression
    Wrongful discharge
    Breach of artists agreement
    Violation of Washington personality rights act


    * Scott Rockenfield is also claiming that Michael Wilton and Eddie Jackson fired him says our source.

    * Eric also alleges management wants Todd La Torre out, and Chris DeGarmo was in on a potential reunion with Geoff Tate, until some of these recent happenings took place.

    Eric has told Metal Sludge directly: “What I’ve seen and heard myself; there’s more to it than that. I will say this; for being such a little guy, Todd (La Torre) has caused a lot of problems.”

    To see a screen capture of the actual lawsuit filed on October 11th 2021, see pages 1 & 2 of 49 below.

    There is no official word from anyone in any of the related Queensryche camps as of this posting.

    We’ll keep you posted as more develops… and remember, you read it here first at Metal Sludge!

    What an absolute Soap Opera these guys are.

    • Haha 1
  9. 1 hour ago, auslander said:

    Harsh! But, agree in a way. They wanted to convince everyone they were a different band. Got rid of their logo (one of the best and most recognised) and also their successful art scheme started with Pyromania. Dumb all round. 

    Yeah, after "Adrenalize" and "The Vault", which contained killer live stuff, this release was too much of a departure for me.

    The "no logo" artwork and Joe Elliot styling his hair to look like Steffi Graf, wasn't a good sign in terms of a classic Leppard album.

  10. This video explains it all and shows the initial clip. I guess the reporter was in a bad position considering it was live. She needs to speak to her lawyers about merchandising rights. She could make a fortune out of this just with coffee mugs and t-shirts alone.

    I didn't know, I do now. Very funny.

    Nice one Dan.

     

     

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